Mutant TEM β-Lactamase Producing Resistance to Ceftazidime, Ampicillins, and β-Lactamase Inhibitors
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چکیده
منابع مشابه
TEM & SHV genes in extended spectrum β-lactamase producing Klebsiella species & their antimicrobial resistance pattern
Background & objectives: Extended spectrum β-lactamases (ESBLs) are often plasmid mediated derived from mutations in the classic TEM and SHV genes by one or more amino acid substitution around the active site. Detection of TEM and SHV genes by molecular methods in ESBL producing bacteria and their pattern of antimicrobial resistance can provide useful information about its epidemiology and risk...
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Avibactam is a novel non-β-lactam β-lactamase inhibitor that is currently undergoing phase 3 clinical trials in combination with ceftazidime. Ceftazidime is hydrolyzed by a broad range of β-lactamases, but avibactam is able to inhibit the majority of these enzymes. The studies described here attempt to provide insight into the amount of avibactam required to suppress bacterial growth in an envi...
متن کاملDetection of β-lactamase-mediated resistance
ß-Lactams are the most widely used antibiotics, and ß-lactamases are the greatest source of resistance to them. Colorimetric tests are good, rapid, indicators of ß-lactamase production and its contingent resistance in Haemophilus, Moraxella and Neisseria spp. They can also be applied to Gram-negative bacilli but are less useful, since the usual question is not whether a ß-lactamase is produced ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2002
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.46.3.646-653.2002